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Novel balloon catheter‐based endobiliary radiofrequency ablation system: Ex‐vivo experimental study
Author(s) -
Inoue Tadahisa,
Ito Kiyoaki,
Yoneda Masashi
Publication year - 2020
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/den.13622
Subject(s) - medicine , balloon , radiofrequency ablation , ablation , balloon catheter , catheter ablation , nuclear medicine , catheter , radiology , surgery
Background Endobiliary radiofrequency ablation (RFA) is a promising treatment option for malignant biliary obstruction, but conventional catheter RFA (Conventional‐RFA) has several limitations. We examined the feasibility of a novel approach to balloon‐based RFA (Balloon‐RFA) with an automatic temperature control system in freshly resected pig livers. Methods Balloon‐RFA application was performed in a step‐by‐step manner at target temperatures of 50°C, 60°C, and 70°C. The temperatures were maintained for 60 s. As a control, Conventional‐RFA was performed at 7 W of power for 90 s, 7 W 120 s, 10 W 90 s, and 10 W 120 s. The ablation areas were measured and compared between Balloon‐RFA and Conventional‐RFA. Results The maximum ablation depths in Balloon‐RFA were 1.86 ± 0.53, 2.29 ± 0.31, and 3.19 ± 0.47 mm at target temperatures of 50, 60, and 70°C, respectively. The maximum ablation depths in Conventional‐RFA were 2.81 ± 0.46, 4.09 ± 0.45, 3.41 ± 0.58, and 4.27 ± 0.29 mm at 7 W 90 s, 7 W 120 s, 10 W 90 s, and 10 W 120 s, respectively. Differences between the minimum and maximum depths were significantly smaller in Balloon‐RFA (0.73 ± 0.31 mm) than in Conventional‐RFA (2.00 ± 0.62 mm; P < 0.001). Excessive ablation occurred only in Conventional‐RFA (0% vs. 67%; P = 0.005). Conclusions The novel balloon‐based RFA system allows ablation to be finely tuned in order to successfully obtain consistent ablation depths and avoid excessive ablation.