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Feasibility and outcomes of anti‐reflux mucosectomy for proton pump inhibitor dependent gastroesophageal reflux disease: First Indian study (with video)
Author(s) -
Patil Gaurav,
Dalal Ankit,
Maydeo Amit
Publication year - 2020
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/den.13606
Subject(s) - medicine , reflux , gerd , dysphagia , proton pump inhibitor , gastroenterology , adverse effect , disease , surgery
Background Anti‐reflux mucosectomy (ARMS) is a newfangled minimally invasive technique, with successful outcomes for the management of gastroesophageal reflux (GER). We present our initial experience (success rate) and safety profile for this procedure. Methods Consecutive patients with daily dependence on proton pump inhibitor (PPI) for GER were prospectively enrolled from September 2016 to August 2019 and underwent ARMS using a cap assisted endoscopic mucosal resection. Severity was assessed by gastroesophageal reflux disease questionnaire. Gastroscopy and 24‐h pH‐metry was done pre and post procedure. Patient characteristics, PPI requirement, adverse events and follow‐up were documented. Results Sixty‐two patients [44 (71%) male] underwent successful ARMS with a mean age (SD) of 36 (9.9) years. Technical success was achieved in 100 % of patients. Intraoperative bleeding was noted in 62 (100%) patients, endoscopic hemostasis was successfully achieved. At follow‐up dysphagia was seen in 5 (8%) patients which needed a single session of endoscopic dilation. At 2 months, mean (SD) DeMeester score normalized in 45 (72.5%) patients from 76.8 (18.3) to 14.3 (6.1) ( P < 0.001). PPI could be stopped in 43 (69.4%) patients. The mean (SD) GERD‐Q score reduced from 10.6 (1.9) to 3.4 (1.5) ( P < 0.001). However, in 12 (19.3%) patients low dose of PPIs was continued, while 7 (11.3%) patients continued full dose. Thirty‐eight (61.3%) patients telephonically reported symptomatic improvement and were off PPIs at 12 months. Conclusions Anti‐reflux mucosectomy is safe and effective for treatment of GER. The long term outcomes are favorable, response is durable and promising at our center. Appropriate patient selection still remains primal to the overall success of ARMS.