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Epstein–Barr virus positivity among surgically resected intramucosal gastric cancer
Author(s) -
Murai Katsuyuki,
Kakushima Naomi,
Sugino Takashi,
Yoshida Masao,
Kawata Noboru,
Tanaka Masaki,
Takizawa Kohei,
Muramatu Koji,
Kusafuka Kimihide,
Bando Etsuro,
Ono Hiroyuki
Publication year - 2018
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/den.13181
Subject(s) - medicine , gastrectomy , pathology , lymph node , infiltration (hvac) , pathological , cancer , adenocarcinoma , histology , stroma , immunohistochemistry , physics , thermodynamics
Epstein–Barr virus‐associated gastric cancer ( EBV ‐ GC ) accounts for approximately 8% of gastric cancers. However, little is known regarding intramucosal EBV ‐ GC . The present study aimed to evaluate endoscopic and clinicopathological characteristics of intramucosal EBV ‐ GC . Pathological data of 172 patients with 173 intramucosal gastric cancers who received gastrectomy with lymph node dissection were obtained for review. EBV ‐encoded small RNA in situ hybridization ( EBER ‐ ISH ) was carried out using a tissue microarray block. Eight intramucosal early gastric cancers (4.6%) were EBER ‐ ISH positive in which no cases had any lymph node metastasis. Macroscopic types were either depressed or flat, dominant histology was mixed type of moderate and poorly differentiated adenocarcinoma. In detail, histological features of “lace pattern” or “lymphocyte infiltration into the stroma or cancer nests” were observed.