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Results of a 36‐year surveillance program for ulcerative colitis‐associated neoplasia in the Japanese population
Author(s) -
Kishikawa Junko,
Hata Keisuke,
Kazama Shinsuke,
Anzai Hiroyuki,
Shinagawa Takahide,
Murono Koji,
Kaneko Manabu,
Sasaki Kazuhito,
Yasuda Koji,
Otani Kensuke,
Nishikawa Takeshi,
Tanaka Toshiaki,
Kiyomatsu Tomomichi,
Kawai Kazushige,
Nozawa Hiroaki,
Ishihara Soichiro,
Morikawa Teppei,
Fukayama Masashi,
Watanabe Toshiaki
Publication year - 2018
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/den.12955
Subject(s) - medicine , ulcerative colitis , colonoscopy , gastroenterology , cumulative incidence , incidence (geometry) , risk factor , dysplasia , population , colorectal cancer , colitis , hazard ratio , cancer , disease , cohort , confidence interval , physics , environmental health , optics
Background and Aim Surveillance colonoscopy has been carried out for patients with long‐standing ulcerative colitis who have an increased risk for colorectal cancer. The aim of the present study was to determine the incidence of and the risk factors for neoplasia. Methods We evaluated 289 ulcerative colitis patients who underwent surveillance colonoscopy between January1979 and December 2014. Cumulative incidence of neoplasia and its risk factors were investigated. Clinical stage and overall survival were compared between the surveillance and non‐surveillance groups. Results Cumulative risk of dysplasia was 3.3%, 12.1%, 21.8%, and 29.1% at 10, 20, 30 and 40 years after the onset of ulcerative colitis, respectively. Cumulative risk of colorectal cancer was 0.7%, 3.2%, 5.2%, and 5.2% at 10, 20, 30 and 40 years from the onset of ulcerative colitis, respectively. Total colitis was a risk factor for neoplasia ( P = 0.015; hazard ratio, 2.96). Conclusions Our surveillance colonoscopy program revealed the incidence and risk factors of ulcerative colitis‐associated neoplasias in the Japanese population. Total colitis is a risk factor for neoplasia.