z-logo
Premium
Ulcerative colitis endoscopic index of severity is associated with long‐term prognosis in ulcerative colitis patients treated with infliximab
Author(s) -
Saigusa Keiichiro,
Matsuoka Katsuyoshi,
Sugimoto Shinya,
Arai Mari,
Kiyohara Hiroki,
Takeshita Kozue,
Mizuno Shinta,
Mori Kiyoto,
Nanki Kosaku,
Takeshita Tatsuya,
Nakazato Yoshihiro,
Yajima Tomoharu,
Naganuma Makoto,
Hisamatsu Tadakazu,
Ogata Haruhiko,
Iwao Yasushi,
Kanai Takanori
Publication year - 2016
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/den.12655
Subject(s) - medicine , infliximab , ulcerative colitis , colonoscopy , gastroenterology , inflammatory bowel disease , retrospective cohort study , disease , colorectal cancer , cancer
Background and Aim Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is characterized by periods of remission and episodes of relapse. Mucosal healing is an emerging therapeutic target in UC and various scoring systems have been used. The UC endoscopic index of severity (UCEIS) is the only validated endoscopic index at present, with minimum interobserver variation. Correlation of UCEIS scores after treatment and clinical outcomes of UC has not been examined. In the present study, we aimed to evaluate the usefulness of UCEIS after treatment with infliximab. Methods The medical records of 82 UC patients, treated with infliximab at Keio University Hospital between October 2010 and July 2013, were reviewed retrospectively. Endoscopic findings were evaluated based on the UCEIS. Results Mean pre‐therapeutic UCEIS score was 5.1. Pre‐therapeutic UCEIS scores were not associated with short‐term outcomes. Forty‐five patients underwent colonoscopy at 3–12 months after starting treatment; mean post‐therapeutic UCEIS score was 2.4, with a score of 0–1 in 16 (35.6%) patients, 2–4 in 19 (42.2%) patients, and 5–8 in 10 (22.2%) patients. Importantly, a post‐therapeutic UCEIS score of 0 or 1 after treatment was associated with a favorable long‐term outcome. Conclusion UCEIS score is a useful instrument for evaluating endoscopic improvement in UC patients treated with infliximab, and mucosal healing may be defined with a UCEIS score of 0 or 1.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here