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Confocal laser endomicroscopy in gastrointestinal and pancreatobiliary diseases
Author(s) -
Nakai Yousuke,
Isayama Hiroyuki,
Shinoura Susumu,
Iwashita Takuji,
Samarasena Jason B.,
Chang Kenneth J.,
Koike Kazuhiko
Publication year - 2014
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/den.12152
Subject(s) - medicine , endoscope , endomicroscopy , endoscopy , confocal , esophagus , radiology , pathological , pathology , surgery , geometry , mathematics
Confocal laser endomicroscopy ( CLE ) is an emerging diagnostic procedure that enables in vivo pathological evaluation during ongoing endoscopy. There are two types of CLE : endoscope‐based CLE ( eCLE ), which is integrated in the tip of the endoscope, and probe‐based CLE ( pCLE ), which goes through the accessory channel of the endoscope. Clinical data of CLE have been reported mainly in gastrointestinal ( GI ) diseases including B arrett's esophagus, gastric neoplasms, and colon polyps, but, recently, a smaller pCLE , which goes through a catheter or a fine‐needle aspiration needle, was developed and clinical data in the diagnosis of biliary stricture or pancreatic cysts have beenincreasingly reported. The future application of this novel technique expands beyond the pathological diagnosis to functional or molecular imaging. Despite these promising data, the generalizability of the procedure should be confirmed especially in J apan and other A sian countries, where the current diagnostic yield for GI luminal diseases is high. Given the high cost of CLE devices, cost–benefit analysis should also be considered.