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Long‐term outcomes of endoscopic submucosal dissection for early gastric cancer: A single‐center retrospective study
Author(s) -
Kosaka Takashi,
Endo Masaki,
Toya Yosuke,
Abiko Yukito,
Kudara Norihiko,
Inomata Masaaki,
Chiba Toshimi,
Takikawa Yasuhiro,
Suzuki Kazuyuki,
Sugai Tamotsu
Publication year - 2014
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/den.12099
Subject(s) - medicine , endoscopic submucosal dissection , single center , retrospective cohort study , cancer , general surgery , surgery , gastroenterology
Background The aim of the present study was to examine the safety and efficacy of endoscopic submucosal dissection ( ESD ) for early gastric cancer ( EGC ) based on the long‐term outcomes. Patients and Methods From J une 2002 to M arch 2007, ESD was carried out in 472 cases and 570 lesions of EGC . Post‐surgical cases and status‐unknown cases were excluded. The following long‐term outcomes were examined in 438 patients who were reliably followed up for at least 5 years after treatment (range: 5 years [60 months] to 9 years, 9 months [117 months]): local recurrence, metachronous recurrences, and the survival rate. Results The overall en bloc resection rate was 97.7% for all lesions treated by ESD . The median procedure time was 47.0 min (range 8–345 min). The incidence of positive horizontal andvertical margins was 3.7% and 3.4%, respectively. The incidence of perforation and postoperative bleeding was 5.3% and 4.3%, respectively. There were no deaths related to ESD . Local recurrence was observed in five patients (1.1%), and metachronous recurrences in 7.8% of the patients. The post‐treatment 5‐year survival was 83.1%. There were no deaths as a result of gastric cancer associated with sites treated by ESD . Conclusion ESD can be considered a standard treatment for EGC based on its expanded indications and low incidences of local recurrence and lymph node metastasis.