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Relation between bile acid reflux into the stomach and the risk of atrophic gastritis and intestinal metaplasia: A multicenter study of 2283 cases
Author(s) -
Matsuhisa Takeshi,
Arakawa Tetsuo,
Watanabe Tetsuo,
Tokutomi Tadashi,
Sakurai Kouichi,
Okamura Seisuke,
Chono Shinji,
Kamada Tomoari,
Sugiyama Atsushi,
Fujimura Yoshinori,
Matsuzawa Kenji,
Ito Masanori,
Yasuda Mitsugu,
Ota Hiroyoshi,
Haruma Ken
Publication year - 2013
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/den.12030
Subject(s) - intestinal metaplasia , gastroenterology , bile reflux , atrophic gastritis , medicine , odds ratio , gastritis , stomach , metaplasia , helicobacter pylori , bile acid
Background The relationship between bile acid reflux into the stomach and the risk of atrophic gastritis and intestinal metaplasia is still not well understood. Towards obtaining a better understanding, concentrations of bile acids were measured. Patients and Methods This study was carried out with the participation of 14 facilities in J apan, and 2283 samples were collected. The subjects with bile acid concentrations equal to or higher than the limit of detection were divided into four groups of equal size (group A : 0–25%, group B : 26–50%, group C : 51–75%, and group D : 76–100%). Thus, including the control group, there were five groups in total. The odds that the control group would develop atrophic gastritis and intestinal metaplasia was set as 1,and the odds ratios ( OR ) in groups A , B , C and D were calculated based on the odds in the control group. Results Regarding the development of atrophic gastritis, no increased risk was observed in either the H elicobacter pylori ( H . pylori )‐positive or ‐negative cases. The OR for the development of intestinal metaplasia were significantly higher, for both cases with and without H . pylori infection, in group D . Conclusion High concentrations of bile acid seem to be associated with an elevated risk of intestinal metaplasia.

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