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Fluorescence optical imaging for the detection of potential psoriatic arthritis in comparison to musculoskeletal ultrasound
Author(s) -
ErdmannKeding Magdalena,
Ohrndorf Sarah,
Werner Stephanie Gabriele,
Glimm AnneMarie,
Burmester GerdRüdiger,
Kokolakis Georgios,
Zuberbier Torsten,
Sterry Wolfram,
Backhaus Marina,
Philipp Sandra
Publication year - 2019
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/ddg.13931
Subject(s) - medicine , psoriatic arthritis , ultrasound , wrist , psoriasis , arthritis , radiology , inflammation , wrist pain , pathology , dermatology
Summary Objective Comparison of fluorescence optical imaging (FOI) with grayscale (GS) and power Doppler ultrasound (PDUS) to detect joint inflammation in patients with confirmed or suspected psoriatic arthritis (PsA). Methods Patients (n = 60) with psoriasis and tenderness and/or swelling of joints were separated into two groups: diagnosis confirmed by the treating dermatologist before the start of the study (n = 26), and suspected PsA (n = 34). GS/PDUS of the hand most clinically affected was performed with a dorsal/palmar view (wrist, MCP, PIP, DIP2–5). FOI examination was carried out in a standardized manner by analyzing the predefined Phases 1–3. Results FOI was found to be more sensitive than ultrasound (US) for detection of inflammation in PIP/DIP joints (p = 0.035). Confirmed PsA patients showed more findings in FOI P2 and P3, while suspected PsA patients showed more findings in P1. In the confirmed PsA group, most involved joints were MCP joints, while in the suspected PsA group, more involved wrist joints and DIP joints (p = 0.006) were detected with FOI. Conclusions The differences between the confirmed and suspected groups indicate that FOI is helpful in the detection of early PsA since P1 may correspond to acute inflammation, whereas P2 and P3 enhancement reflect chronic inflammation. Fluorescence optical imaging might therefore be a novel diagnostic tool for early PsA diagnosis.