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ABCB1 gene is associated with the risk of bullous pemphigoid in a polish population
Author(s) -
RychlikSych Mariola,
Barańska Małgorzata,
Dudarewicz Michał,
Skrętkowicz Jadwiga,
Żebrowska Agnieszka,
Owczarek Jacek,
Waszczykowska Elżbieta
Publication year - 2017
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/ddg.13182
Subject(s) - genotype , bullous pemphigoid , allele , population , medicine , polymorphism (computer science) , immunology , allele frequency , gene , gastroenterology , biology , genetics , antibody , environmental health
Summary Background and objectives Polymorphisms in the P‐glycoprotein‐encoding ABCB1 gene may affect the intracellular concentration of xenobiotics, and thus contribute to the development of autoimmune diseases, including bullous pemphigoid (BP). The objective of the present study was to investigate whether there is an association between the C3435T and G2677T/A polymorphisms in the ABCB1 gene and the risk of BP in a Polish population. Patients and methods The study included 71 patients with BP and 156 healthy volunteers. Determination of the C3435T polymorphism was carried out using PCR‐RFLP; the G2677T/A polymorphism, using allele‐specific PCR. Results While there was no correlation between the C3435T polymorphism and the risk of BP, we did find such an association with respect to the G2677T/A polymorphism. The relative risk of BP was more than five times greater in individuals with the 2677TA genotype (OR = 5.52, p = 0.0063), and more than twice as high in carriers of the 2677TT genotype (OR = 2.40, p = 0.0076). At 2.40 (0.000018), the OR in carriers of the 2677T allele was also increased. The greater prevalence of the 2677GG genotype and the 2677G allele in the control group, as well as the OR < 1.0 (0.22 and 0.33, respectively), suggest a protective role of the 2677G allele with respect to the development of BP. Conclusions The results of the present study indicate that the G2677T/A polymorphism in the ABCB1 gene may affect the risk of developing BP.