Premium
Incidence of autoimmune bullous diseases in Serbia: a 20‐year retrospective study
Author(s) -
Milinković Mirjana V.,
Janković Slavenka,
Medenica Ljiljana,
Nikolić Miloš,
Reljić Vesna,
Popadić Svetlana,
Janković Janko
Publication year - 2016
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/ddg.13081
Subject(s) - medicine , incidence (geometry) , bullous pemphigoid , pemphigus , epidermolysis bullosa acquisita , pemphigoid , dermatitis herpetiformis , epidemiology , dermatology , population , retrospective cohort study , disease , pediatrics , immunology , environmental health , antibody , physics , optics
Summary Background and objectives While most previous surveys on the clinico‐epidemiological features of autoimmune bullous diseases (AIBDs) have predominantly focused on a single disease entity or just one disease group, there have been only few studies examining the incidence of various AIBDs. In the present study, we set out to determine the spectrum of AIBDs, to estimate the incidence of the most common AIBDs, and to examine their temporal trends in Central Serbia over a period of 20 years. Methods We retrospectively recruited 1,161 new AIBD cases diagnosed in Central Serbia during the period from January 1991 to December 2010. The diagnosis was based on strict clinical, histological, and immunohistological evaluation. Results The incidence rates were: 4.35 per million population/year (pmp/year) for pemphigus, 4.47 pmp/year for pemphigoid, 1.42 pmp/year for dermatitis herpetiformis (DH), 0.25 pmp/year for linear IgA disease, and 0.08 pmp/year for epidermolysis bullosa acquisita. In the period observed, age‐adjusted incidence rates significantly increased for pemphigus and particularly for pemphigoid, whereas they decreased, albeit not significantly, for DH. Conclusions For the first time, our study evaluates the incidence rates of the entire spectrum of AIBDs in Serbia, and examines their temporal trends over a 20‐year period. To the best of our knowledge, our finding of similar incidence rates for pemphigus and pemphigoid has previously not been reported.