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Laser‐assisted drug delivery: mode of action and use in daily clinical practice
Author(s) -
Braun Stephan Alexander,
Schrumpf Holger,
Buhren Bettina Alexandra,
Homey Bernhard,
Gerber Peter Arne
Publication year - 2016
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/ddg.12963
Subject(s) - mode of action , drug , action (physics) , medicine , clinical practice , pharmacology , chemistry , physical therapy , biochemistry , physics , quantum mechanics
Summary Topical application of pharmaceutical agents is a basic principle of dermatological therapy. However, the effective barrier function of the skin significantly impairs the bioavailability of most topical drugs. Fractional ablative lasers represent an innovative strategy to overcome the epidermal barrier in a standardized, contact‐free manner. The bioavailability of topical agents can be significantly enhanced using laser‐assisted drug delivery (LADD). In recent years, the principle of LADD has become well established for various dermatological indications. Herein, we review the current literature on LADD and present potential future applications.