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Epidermal barrier in hereditary ichthyoses, atopic dermatitis, and psoriasis
Author(s) -
Schmuth Matthias,
Blunder Stefan,
Dubrac Sandrine,
Gruber Robert,
MoosbruggerMartinz Verena
Publication year - 2015
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/ddg.12827
Subject(s) - psoriasis , atopic dermatitis , dermatology , skin barrier , epidermis (zoology) , barrier function , medicine , ichthyosis , immunology , biology , microbiology and biotechnology , anatomy
Summary Several skin disorders are associated with impaired skin barrier function. Primary dysfunction is caused by monogenic defects in key components of the epidermis (for example ichthyoses). Secondary barrier impairment occurs in inflammatory dermatoses marked by disturbed epidermal homeostasis (eczema, psoriasis, etc.). In these disorders, inflammation impedes the synthesis or maintenance of skin barrier components. Recent evidence suggests a combination of primary and secondary barrier dysfunction in atopic dermatitis and, to a lesser extent, also in psoriasis. In the future, subtypes of atopic dermatitis may likely be defined, in which one or the other is prevalent.