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A 36‐week retrospective open trial comparing the efficacy of biological therapies in nail psoriasis
Author(s) -
Bardazzi Federico,
Antonucci Valentina A.,
Tengattini Vera,
Odorici Giulia,
Balestri Riccardo,
Patrizi Annalisa
Publication year - 2013
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/ddg.12173
Subject(s) - medicine , psoriasis , etanercept , adalimumab , ustekinumab , infliximab , dermatology , nail (fastener) , psoriatic arthritis , retrospective cohort study , psoriasis area and severity index , nail disease , onycholysis , surgery , tumor necrosis factor alpha , materials science , metallurgy
Summary Background Nail psoriasis occurs in about 50% of psoriatic patients and can be psychologically devastating since it appears on visible areas. Up to now there is no evidence about what biological drugs is the most effective on nail psoriasis. Objectives The aim of our study was to determine if one of the four biological drugs approved in our country (infliximab, adalimumab, etanercept, ustekinumab) is more effective than the others for nail psoriasis. Materials and methods A single‐center, retrospective study was conducted to assess the efficacy of biological therapies in patients with moderate to severe psoriasis with nail involvement. NAPSI was evaluated in all psoriatic patients. Kruskal‐Wallis and Fisher's exact tests were used to analyze the data. Results A global statistically significant improvement in mean NAPSI from baseline to 12, 24 and 36 weeks was observed in all patients. At 12 weeks 27.78% of the patients reach NAPSI 75, at 24 weeks 81.48% and at 36 weeks 88.89%. The improvement in nail psoriasis is not significantly different between groups. An improvement in the mean Psoriasis Area and Severity Index score was also achieved Conclusions Biological therapies have shown to ameliorate psoriatic nail lesions. We did not find any statistically significant differences between the four biological drugs investigated.