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Bacteriological pathogen spectrum of chronic leg ulcers: Results of a multicenter trial in dermatologic wound care centers differentiated by regions
Author(s) -
Jockenhöfer Finja,
Gollnick Harald,
Herberger Katharina,
Isbary Georg,
Renner Regina,
Stücker Markus,
Valesky Eva,
Wollina Uwe,
Weichenthal Michael,
Karrer Sigrid,
Klode Joachim,
Dissemond Joachim
Publication year - 2013
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/ddg.12170
Subject(s) - proteus mirabilis , pseudomonas aeruginosa , staphylococcus aureus , medicine , multicenter study , wound care , broad spectrum , proteus , bacteria , microbiology and biotechnology , surgery , escherichia coli , randomized controlled trial , biology , biochemistry , chemistry , genetics , combinatorial chemistry , gene
Summary Background In almost every chronic wound different bacteria species can be detected. Patients and methods Retrospective, multicenter evaluation of bacterial swab results from 2010 and 2011 in patients with chronic leg ulcer treated in 10 dermatologic wound care centers from 5 regions in Germany. Results Data of 970 patients were analyzed. Staphylococcus aureus was detected in 47.6 % of the patients, 8.6% of these were methicillin‐resistant (MRSA). Pseudomonas aeruginosa was found in 31.1 %, enterobacteria in 28.6 % and Proteus mirabilis in 13.7 % of the patients. The regional comparison showed a significant south‐north gradient for S. aureus, P. aeruginosa , and enterobacteria. Moreover, a highly significant west‐east gradient for MRSA was found with detection rates of 13.5 % in the west to 4.0 % in the east. Furthermore, nationally there was a significant negative correlation between S. aureus and P. aeruginosa or P. mirabilis , respectively, as well as a positive correlation of P. aeruginosa with respect to wound size and duration. In addition to climatic and therapeutic conditions, different regional health care structures are discussed as potentially relevant reasons for these significantly different regional detection rates. Conclusions Our data show the regional variability of the spectrum of currently detected bacteria in patients with chronic leg ulcers in Germany.