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Thyroid metastasis of pulmonary adenocarcinoma with EGFR G719A mutation: Genetic confirmation with liquid‐based cytology specimens
Author(s) -
Yamada Yosuke,
Shirahase Hiroyuki,
Fukiya Mika,
Yoshizawa Akihiko,
Minamiguchi Sachiko,
Ozasa Hiroaki,
Haga Hironori
Publication year - 2021
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1111/cyt.12940
Subject(s) - medicine , adenocarcinoma , pulmonary adenocarcinoma , cytology , pathology , genetic testing , mutation , metastasis , lung , lung cancer , thyroid , cancer , gene , biology , genetics
Presented is a case of advanced pulmonary adenocarcinoma and a thyroid tumour with calcification. EGFR gene mutation testing of the thyroid aspirate specimen revealed a G719A point mutation in exon 18 that was identical to that in the patient's known lung cancer. This case demonstrates the usefulness of liquid‐based cytology samples, which enable genetic testing leading to a conclusive diagnosis while preserving the cytological specimens.