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Cytological diagnosis of primary pineal germ cell tumour with a yolk sac component in cerebrospinal fluid
Author(s) -
Kalogeraki Alexandra,
Tamiolakis Dimitrios,
Katzilakis Nikolaos,
Pelagiadis Iordanis,
Raissaki Maria,
Stiakaki Eftichia
Publication year - 2020
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1111/cyt.12792
Subject(s) - cerebrospinal fluid , medicine , yolk sac , pathology , germinoma , cytology , malignancy , lymphoma , germ cell , radiology , biology , radiation therapy , embryo , biochemistry , gene , microbiology and biotechnology
We report the clinicocytopathological and immunocytopathological findings of a 13 year old male with mixed germ cell tumor including yolk sac elements. This case was diagnosed by cytology and confirmed by immunocytochemistry in cerebrospinal fluid smears. MRI findings favored malignancy such as lymphoma and germinoma. As beta‐Η CG was elevated in serum and cerebrospinal fluid, lymphoma was ruled out and histological confirmation of the diagnosis of germinoma was not necessary. The presence of AFP positive, β HCG positive, c‐kit positive, and PLAP positive cells, established the diagnosis.