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Accuracy of grading pancreatic neuroendocrine neoplasms with Ki‐67 index in fine‐needle aspiration cellblock material
Author(s) -
Grosse Claudia,
Noack Petar,
Silye Rene
Publication year - 2019
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1111/cyt.12643
Subject(s) - medicine , grading (engineering) , neuroendocrine tumors , fine needle aspiration , radiology , pathology , biopsy , civil engineering , engineering
Objective The aim of this study was to assess the preoperative tumour grade of pancreatic neuroendocrine neoplasms (panNENs) by determining the Ki‐67 index in endoscopic ultrasound‐guided fine needle aspiration ( EUS ‐ FNA ) material and to correlate the preoperative tumour grade with the postoperative tumour grade in surgical specimens. Methods We performed a retrospective review of the institutional pathology database over a 10‐year period (2007‐2017) to identify all cases of panNENs with corresponding preoperative EUS ‐ FNA cytological material and surgical specimens. Fifteen cases with adequate EUS ‐ FNA material (more than 400 tumour cells on cellblock) were identified. The cytological and histological samples were graded based on the mitotic rate and the Ki‐67 index in accordance with the 2017 World Health Organisation grading system for panNENs. The tumour grades determined on EUS ‐ FNA cellblock material were compared with the histological tumour grades. Results Mean age at diagnosis was 64.8 ± 12.7 years (range, 38‐85 years). The grading scores assigned to the cytological and histological samples were concordant in all 15 (100%) cases. Of those, two (13%) cases were scored as grade 1, nine (60%) cases as grade 2 and four (27%) cases as grade 3 tumours. Conclusion Our study shows that tumour grade in patients with PanNENs can be reliably determined by assessing the Ki‐67 index in EUS ‐ FNA specimens based on the 2017 World Health Organisation classification and grading system.