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Endometrial carcinoma in high‐risk populations: is it time to consider a screening policy?
Author(s) -
Fambrini M.,
Sorbi F.,
Sisti G.,
Cioni R.,
Turrini I.,
Taddei G.,
Guaschino S.
Publication year - 2014
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1111/cyt.12131
Subject(s) - medicine , endometrial cancer , cytopathology , gynecology , incidence (geometry) , psychological intervention , developed country , public health , malignancy , family medicine , cancer , environmental health , cytology , population , pathology , nursing , physics , optics
Endometrial carcinoma ( EC ) is the leading female genital tract malignancy in industrialized countries. It will become an important public health problem in the coming years in the USA and Europe, where its incidence is increasing, and next‐generation interventions should include periodical screening in high‐risk women. In this review, we discuss the importance to gynaecologists of detecting women at high risk and offering an adequate screening programme. Screening for EC is particularly challenging and there is currently no proven programme for the surveillance of women estimated to be at an increased risk of developing this form of cancer. The data in the literature, including this and previous issues of Cytopathology , and personal experience suggest that endometrial liquid‐based cytology ( LBC ) might play an essential role in a screening policy for EC . LBC may enable practitioners to reduce age‐adjusted mortality for women at high risk for EC .