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A case of endocrine mucin‐producing sweat gland carcinoma with distant metastasis
Author(s) -
Hadi Rouba,
Xu Haodong,
Barber Brittany R.,
Shinohara Michi M.,
Moshiri Ata S.
Publication year - 2021
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13999
Subject(s) - pathology , metastasis , medicine , mucinous carcinoma , mucin , cytokeratin , immunohistochemistry , sweat gland , carcinoma , ductal carcinoma , endocrine system , adenocarcinoma , cancer , breast cancer , sweat , hormone
Abstract Endocrine mucin‐producing sweat gland carcinoma (EMPSGC) is a rare cutaneous adnexal neoplasm typically arising on the face of older individuals, most commonly around the eyelids. Histopathologic features include a circumscribed proliferation of low‐grade epithelioid cells with areas of cystic and cribriform growth, foci of intracytoplasmic and extracellular mucin, and coexpression of endocrine, neuroendocrine, and cytokeratin markers by immunohistochemistry. Given histopathologic and immunohistochemical similarities, EMPSGC is often likened to solid papillary carcinoma of the breast and endocrine ductal carcinoma in situ, and is thought by many to represent a forme fruste of mucinous carcinoma of the skin. To date, the vast majority of reported cases of EMPSGC have been described as having indolent behavior, with no cases of distant metastasis yet reported. Here we report a unique case of EMPSGC that recurred over several years following standard surgical excision and Mohs micrographic surgery, with subsequent metastasis to the parotid gland and axial skeleton.