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Primary cutaneous malignant melanoma in Rett syndrome: Report of a case with nuclear features resembling herpes simplex virus cytopathic effects—a hitherto unrecognized morphological variant
Author(s) -
Petkar Mahir Abdulla,
Rodrigo Thushara
Publication year - 2021
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13943
Subject(s) - pathology , melanoma , herpes simplex virus , mecp2 , medicine , cytopathic effect , biology , virus , cancer research , virology , gene , genetics , phenotype
Rett syndrome (RTT) is a progressive neurological disorder, affecting females with mutations in the X‐linked gene methyl‐CpG‐binding protein 2 ( MECP2 ). While MECP2 has been implicated in cancers of the breast, colon, and prostrate, cancer in patients with RTT is rare. We present a case of malignant melanoma in a patient with RTT, which additionally, displayed hitherto undescribed nuclear features, resembling herpes simplex virus cytopathic effects.