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Metaplastic spiradenocarcinoma: Report of two cases with sarcomatous differentiation
Author(s) -
Held Laura,
Ruetten Arno,
Saggini Andrea,
Kempter Wolfgang,
Tiedke Carmen,
WeberKuhn Susanne,
De Saint Aubain Nicolas,
Mentzel Thomas
Publication year - 2021
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13897
Subject(s) - cylindroma , pathology , sweat gland , differential diagnosis , medicine , neoplasm , sweat
Spiradenocarcinoma (SC) is a very rare malignant skin adnexal tumor with sweat gland differentiation that develops from a pre‐existing spiradenoma, cylindroma, or hybrid tumor called spiradenocylindroma, or arises de novo . We present two exceptionally rare SC cases showing sarcomatous differentiation; we also discuss the clinicopathologic features of SC, as well as its differential diagnoses and available therapeutic modalities. Given the aggressive behavior of SC, rapid diagnosis and complete removal of the tumor with tumor‐free margins is mandatory. Owing to the marked morphological heterogeneity of individual SC cases, dermatopathologists must be familiar with the different possible histopathologic manifestations of this neoplasm.