Premium
Microcystic adnexal carcinoma with germinative follicular differentiation
Author(s) -
MoyaMartínez Cristina,
TorreCastro Juan,
MendozaCembranos Dolores,
Santonja Carlos,
Requena Luis
Publication year - 2021
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13869
Subject(s) - pathology , apocrine , follicular phase , immunohistochemistry , biology , carcinoma , neoplasm , medicine , endocrinology
Microcystic adnexal carcinoma (MAC) is a low‐grade adnexal carcinoma with controversial lines of differentiation. We present here an example of MAC showing histopathologic findings of germinative follicular differentiation in the form of solid aggregates of trichoblastoma intermingled with neoplastic aggregates of MAC. Immunohistochemical findings, showing positivity for PHLDA1 and negativity for BerEp4 in neoplastic aggregates of trichoblastoma, also supported a germinative follicular differentiation. Follicular differentiation in MAC supports an apocrine line of differentiation for this neoplasm.