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Cutaneous Epstein‐Barr virus‐associated smooth muscle tumor in immunosuppression
Author(s) -
Matin Rubeta N.,
Ieremia Eleni
Publication year - 2021
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13849
Subject(s) - pathology , epstein–barr virus , immunosuppression , virus , immunohistochemistry , neoplasm , biopsy , transplantation , in situ hybridization , medicine , biology , immunology , biochemistry , gene expression , gene
A 36‐year‐old renal transplant recipient presented 15 months post‐transplantation with a cutaneous spindle cell neoplasm with features of smooth muscle differentiation treated with local excision. 1.4 years later, a magnetic resonance imaging liver scan with gadolinium demonstrated multiple bilobar enhancing hepatic lesions, in keeping with metastases. A core biopsy revealed morphological appearances similar to the previous cutaneous spindle cell neoplasm. Epstein‐Barr virus early RNA (EBER) in situ hybridization demonstrated strong diffuse staining of both cutaneous and liver tumor cells for EBER indicative of Epstein‐Barr virus (EBV) infection. This is a rare presentation of multifocal EBV‐associated smooth muscle tumors first presenting in the skin in an adult renal transplant recipient, which, despite being multifocal and involving the liver, may confer a better prognosis than predicted.