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Oral focal mucinosis: A multi‐institutional study and literature review
Author(s) -
Silva Cunha John Len,
Leite Amanda Almeida,
Castro Abrantes Thamiris,
Vervloet Lorena Passoni,
Lima Morais Thayná Melo,
Oliveira Paiva Neto Gerson,
Kimura Tatiayara Libório,
Ferreira Sônia Maria Soares,
AlbuquerqueJúnior Ricardo Luiz Cavalcanti,
Abrahão Aline Corrêa,
Romañach Mario José,
Benevenuto de Andrade Bruno Augusto,
Almeida Oslei Paes,
Soares Ciro Dantas
Publication year - 2021
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13813
Subject(s) - medicine , pathology , h&e stain , immunohistochemistry , cd34 , etiology , staining , mucinosis , differential diagnosis , asymptomatic , soft tissue , dermatology , biology , stem cell , genetics
Background Oral focal mucinosis (OFM) is a rare benign condition of unknown etiology, considered the oral counterpart of cutaneous focal mucinosis. We report the clinicopathologic features of 21 cases of OFM in conjunction with a review of the literature. Methods Clinical data were collected from the records of five oral and maxillofacial pathology services. All cases were evaluated by hematoxylin and eosin staining, histochemistry, and immunohistochemistry (vimentin, S‐100, α‐SMA, CD34, and mast cell). Results The series comprised 14 females (66.7%) and seven males (33.3%), with a mean age of 48.2 ± 20.7 years (range: 8‐77 years) and a 2:1 female‐to‐male ratio. Most of the lesions affected the gingiva (n = 6, 28.6%) and presented clinically as asymptomatic sessile or pedunculated nodules with fibrous or hyperplasic appearance. All cases were negative for S‐100 protein, CD34, and α‐SMA and positive for Alcian blue staining. Conservative surgical excision was the treatment in all cases, and there was only one recurrence. Conclusion OFM is a rare benign disorder that is often clinically misdiagnosed as reactive lesions or benign proliferative processes. Dermatologists and pathologists should consider OFM in the differential diagnosis of soft tissue lesions in the oral cavity, mainly located in the gingiva.