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A case of primary cutaneous B‐cell lymphoma with immature features in an old man. Diffuse large B‐cell lymphoma with immature features or B‐cell lymphoblastic lymphoma?
Author(s) -
Ronchi Andrea,
Zito Marino Federica,
Vitiello Paola,
Caccavale Stefano,
Argenziano Giuseppe,
Crisci Stefania,
Franco Renato,
Sica Antonello
Publication year - 2021
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13795
Subject(s) - lymphoma , lymphoblastic lymphoma , pathology , b cell , immunohistochemistry , diffuse large b cell lymphoma , marginal zone , medicine , differential diagnosis , gene rearrangement , biology , antibody , immunology , t cell , gene , immune system , biochemistry
Primary cutaneous B‐cell lymphomas are a heterogeneous group of lymphoid neoplasms primarily occurring in the skin. Although most cases are represented by primary cutaneous follicle center cell lymphoma, primary cutaneous marginal zone lymphoma and leg‐type diffuse large B‐cell lymphoma, other diffuse large B‐cell lymphomas and B‐cell lymphoblastic lymphoma may rarely present primarily in the skin. In this setting, the presence of histopathologic and immunohistochemical features of cellular immaturity is exceedingly rare and may represent a diagnostic challenge. We present the first case of a primary cutaneous diffuse large B‐cell lymphoma characterized by diminished expression of CD45, expression of TdT and rearrangement of MYC gene. The differential diagnosis mainly included B‐cell lymphoblastic lymphoma, and required the genetic analysis of heavy chain (IGH) gene rearrangements.