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BAP1‐inactivated melanocytic tumor with preserved BAP1 expression? Morphology to the rescue!
Author(s) -
Duncan Lyn M.,
Tetzlaff Michael T.
Publication year - 2020
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13671
Subject(s) - bap1 , pathology , biology , cancer research , medicine , melanoma
BAP1‐inactivated melanocytic tumors typically present with distinctive histopathological changes and loss of nuclear BAP1 protein expression. Rare cases exhibit the typical morphology but with preserved expression of BAP1. In the current issue of Journal of Cutaneous Pathology , Linos et al. describe such a case and provide a comprehensive molecular‐genetic exploration to explain such a phenomenon.