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Multidrug resistant gastrointestinal stromal tumor with multiple metastases to the skin and subcutaneous soft tissue: A case report and review of literature
Author(s) -
Aickara Divya J.,
McBride Jeffrey,
Morrison Brian,
Romanelli Paolo
Publication year - 2020
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13611
Subject(s) - gist , sunitinib , stromal tumor , medicine , imatinib , soft tissue , pathology , tyrosine kinase inhibitor , metastasis , stromal cell , oncology , cancer research , cancer , renal cell carcinoma , myeloid leukemia
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms which account for less than 1% of all gastrointestinal malignancies. Of all the extra‐abdominal metastases of GIST, superficial soft tissue metastases are the rarest. Previous reports have found success with sunitinib in imatinib‐resistant GIST, but we report a certain wild‐type KIT mutation GIST with cutaneous and subcutaneous metastasis that was unresponsive to multiple tyrosine kinase inhibitor (TKI) treatments. This case illustrates that knowing the specific type of KIT mutations may uncover resistance of certain GIST's to TKIs, necessitating more targeted and alternative therapy.