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Syringocystadenoma papilliferum associated with verrucous carcinoma of the skin in the same lesion: Report of four cases
Author(s) -
AlegríaLanda Victoria,
JoVelasco Margarita,
Santonja Carlos,
Eraña Itziar,
VergaraSanchez Aranzazú,
Kutzner Heinz,
Requena Luis
Publication year - 2020
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13572
Subject(s) - immunohistochemistry , pathology , lesion , medicine , polymerase chain reaction , verrucous carcinoma , dermatology , carcinoma , biology , gene , biochemistry
The association of syringocystadenoma papilliferum (SCAP) with verrucous carcinoma (VC) of the skin in the same lesion is a rare, but well‐documented event. Although human papillomaviruses (HPV) have been proposed to have an etiologic role in the development of the verrucous proliferations associated with SCAP, most of the immunohistochemical and molecular studies have failed to show the presence of their genomic material in these lesions. We report a series of four cases of SCAP associated with VC in anogenital lesions. In two of the cases, we demonstrated the presence of the BRAF V600E mutation by polymerase chain reaction and immunohistochemistry, both in the glandular and in the squamous component. No HPV‐related histopathologic changes were found, nor could the presence of viral DNA be showed.