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Reflectance confocal microscopy may enhance the accuracy of histopathologic diagnosis: A case series
Author(s) -
Shahriari Neda,
GrantKels Jane M.,
Rabinovitz Harold,
Oliviero Margaret,
Scope Alon
Publication year - 2019
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13548
Subject(s) - histopathology , pathology , biopsy , lesion , histopathological examination , confocal microscopy , gold standard (test) , confocal , medicine , reflectivity , radiology , biology , optics , physics , microbiology and biotechnology
Although histopathology is the time‐honored gold standard diagnostic measure in dermatology, several factors may detract from an accurate microscopic diagnosis. Limiting factors include: human error, suboptimal biopsy‐site selection or biopsy technique, and inherent restrictions of vertical tissue sectioning that lead to incomplete microscopic evaluation of the lesion. Reflectance confocal microscopy (RCM) is a non‐invasive imaging tool that allows for the cellular‐level examination of the lesion, at a horizontal plane, which may complement the subsequent vertical histopathological tissue examination. Herein, we report a case series whereby prebiopsy RCM examination enhanced the accuracy of histopathological diagnosis or allowed for a critical appraisal of initial histopathological misdiagnosis.