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Cutaneous metastases of papillary renal cell carcinoma: A case report and review of the literature
Author(s) -
Cardwell Leah A.,
Bender Nicole R.,
Sokumbi Olayemi
Publication year - 2019
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13546
Subject(s) - pathology , nuclear atypia , papillary renal cell carcinomas , eosinophilic , basophilic , medicine , atypia , clear cell , histopathology , dermis , renal cell carcinoma , immunohistochemistry
Papillary renal cell carcinoma (RCC) is an uncommon subtype of RCC that is typically encountered at early stages and has a high survival rate. Histopathology typically shows well‐defined papillary architecture with tumor cells lining fibrovascular cores and can be further subdivided into type 1 and type 2 tumors based on cytology and genetic basis. Type 1 tumors have a single layer of basophilic cells and low nuclear atypia, while type 2 tumors have a pseudostratified layer of eosinophilic cells and high nuclear atypia. Some tumors have overlapping features of both types. We present a unique case of cutaneous metastases of papillary RCC with typical papillary architecture in the dermis and review the literature on this rare entity.