A case of S‐100‐negative CD1a‐positive indeterminate cell histiocytosis | Zendy

Amin Sima | Zendy; Jamerson Jordan | Zendy; Tee Ronald G. | Zendy; Parekh Palak | Zendy

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A case of S‐100‐negative CD1a‐positive indeterminate cell histiocytosis

Author(s) -

Amin Sima,

Jamerson Jordan,

Tee Ronald G.,

Parekh Palak

Publication year - 2019

Publication title -

journal of cutaneous pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.597

H-Index - 75

eISSN - 1600-0560

pISSN - 0303-6987

DOI - 10.1111/cup.13542

Subject(s) - langerin , histiocyte , pathology , histiocytosis , langerhans cell histiocytosis , birbeck granules , medicine , histopathology , biopsy , bone marrow , indeterminate , langerhans cell , dendritic cell , immunology , immune system , disease , mathematics , pure mathematics

Histiocytoses are a group of rare disorders characterized by a proliferation of monocytes/macrophages and dendritic cells. We present a case of a 3‐year‐old girl with a diffuse papular eruption without systemic symptoms demonstrating a proliferation of strongly CD1a + histiocytes, but negative for S‐100 and langerin on histopathology. Systemic work‐up including bone marrow biopsy was unremarkable, and the patient received a diagnosis of CD1a + S − 100‐indeterminate cell histiocytosis.

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