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A case of S‐100‐negative CD1a‐positive indeterminate cell histiocytosis
Author(s) -
Amin Sima,
Jamerson Jordan,
Tee Ronald G.,
Parekh Palak
Publication year - 2019
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13542
Subject(s) - langerin , histiocyte , pathology , histiocytosis , langerhans cell histiocytosis , birbeck granules , medicine , histopathology , biopsy , bone marrow , indeterminate , langerhans cell , dendritic cell , immunology , immune system , disease , mathematics , pure mathematics
Histiocytoses are a group of rare disorders characterized by a proliferation of monocytes/macrophages and dendritic cells. We present a case of a 3‐year‐old girl with a diffuse papular eruption without systemic symptoms demonstrating a proliferation of strongly CD1a + histiocytes, but negative for S‐100 and langerin on histopathology. Systemic work‐up including bone marrow biopsy was unremarkable, and the patient received a diagnosis of CD1a + S − 100‐indeterminate cell histiocytosis.