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Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease
Author(s) -
Coleman Emily,
Panse Gauri,
Cowper Shawn,
Prebet Thomas,
Gore Steven,
Leventhal Jonathan
Publication year - 2019
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13537
Subject(s) - medicine , panniculitis , pathology , myeloid leukemia , leukemia cutis , myeloid , pyoderma gangrenosum , differential diagnosis , disease , leukemia , dermatology , immunology , bone marrow
Cutaneous toxicities to DNA methyltransferase inhibitors are variable and include localized injection site reactions, ecchymoses, maculopapular eruptions, and neutrophilic dermatoses including pyoderma gangrenosum, Sweet syndrome, and neutrophilic eccrine hidradenitis. This series describes two patients diagnosed with lobular neutrophilic panniculitis arising during treatment of acute myelogenous leukemia with “hypomethylating drugs,” including the first report of its occurrence with a next‐generation agent. Differential diagnoses, histopathologic characteristics, treatment considerations, and proposed pathogenesis will be discussed.