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Multiple keratin granulomata: A potential histologic clue to cutaneous squamous cell carcinoma responding to programmed cell death protein 1 inhibitor therapy
Author(s) -
Kahn Benjamin J.,
Parker Douglas,
Yushak Melinda,
Stoff Benjamin,
Blalock Travis W.
Publication year - 2019
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13447
Subject(s) - pembrolizumab , keratin , pathology , programmed cell death 1 , medicine , immunohistochemistry , programmed cell death , cell , keratin 8 , immunotherapy , biology , cancer , pd l1 , apoptosis , biochemistry , genetics
We present histologic features of a locally advanced cutaneous squamous cell carcinoma (cSCC) treated with the programmed cell death protein‐1 (PD‐1) antagonist, pembrolizumab, with a partial response. This contributes to a growing body of literature supporting the efficacy of pembrolizumab in treatment of surgically unresectable cSCC. We also provide a detailed description of the histologic features, particularly keratin granulomata with adjacent lymphocytic aggregates and fibrosis, observed in cSCC under treatment with a PD‐1 antagonist.