Multiple keratin granulomata: A potential histologic clue to cutaneous squamous cell carcinoma responding to programmed cell death protein 1 inhibitor therapy | Zendy

Kahn Benjamin J. | Zendy; Parker Douglas | Zendy; Yushak Melinda | Zendy; Stoff Benjamin | Zendy; Blalock Travis W. | Zendy

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Multiple keratin granulomata: A potential histologic clue to cutaneous squamous cell carcinoma responding to programmed cell death protein 1 inhibitor therapy

Author(s) -

Kahn Benjamin J.,

Parker Douglas,

Yushak Melinda,

Stoff Benjamin,

Blalock Travis W.

Publication year - 2019

Publication title -

journal of cutaneous pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.597

H-Index - 75

eISSN - 1600-0560

pISSN - 0303-6987

DOI - 10.1111/cup.13447

Subject(s) - pembrolizumab , keratin , pathology , programmed cell death 1 , medicine , immunohistochemistry , programmed cell death , cell , keratin 8 , immunotherapy , biology , cancer , pd l1 , apoptosis , biochemistry , genetics

We present histologic features of a locally advanced cutaneous squamous cell carcinoma (cSCC) treated with the programmed cell death protein‐1 (PD‐1) antagonist, pembrolizumab, with a partial response. This contributes to a growing body of literature supporting the efficacy of pembrolizumab in treatment of surgically unresectable cSCC. We also provide a detailed description of the histologic features, particularly keratin granulomata with adjacent lymphocytic aggregates and fibrosis, observed in cSCC under treatment with a PD‐1 antagonist.

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