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Matrical carcinoma with melanocytic hyperplasia mimicking nodular melanoma in an elderly Mexican male
Author(s) -
Lehmer Larisa,
Carly Sama K.,
Feraudy Sebastien
Publication year - 2019
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13445
Subject(s) - pathology , melanoma , basal cell carcinoma , medicine , carcinoma , hmb 45 , nuclear atypia , dermatology , basal cell , immunohistochemistry , cancer research
Matrical carcinoma with melanocytic hyperplasia (MCMH), previously referred to as malignant melanocytic matricoma, is a rare variant of the uncommon pilomatrical carcinoma, occurring most often on the head/neck and upper backs of middle‐aged men. Nodular lesions may resemble pigmented basal cell carcinoma or melanoma clinically. We present a case of MCMH in a Hispanic patient with history of melanoma. Histopathological clues to appropriate diagnosis include basaloid cells, numerous atypical mitotic figures, matrical differentiation, shadow cells, strong diffuse nuclear and cytoplasmic expression of ß‐catenin, and interspersed pigmented dendritic melanocytes.