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Cutaneous involvement as the first manifestation of T‐lymphoblastic lymphoma and review of the literature
Author(s) -
MontesTorres Andrea,
LlamasVelasco Mar,
Capusan Tania M.,
Aguado Beatriz,
Adrados Magdalena
Publication year - 2019
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13431
Subject(s) - lymphoblastic lymphoma , medicine , pathology , lymphoma , cd99 , dermis , terminal deoxynucleotidyl transferase , immunohistochemistry , t cell , immunology , tunel assay , vimentin , immune system
Lymphoblastic lymphomas (LBLs) are uncommon malignant neoplasms derived from immature T‐ or B‐lymphoid progenitor cells. Although cutaneous involvement may reach 33% in B‐LBL, only 12 cutaneous cases of T‐LBL have been published. We report the case of a 49‐year‐old woman with 2‐month history of erythematous‐violaceous plaques in the sternal region and breasts. Histopathologic examination showed a dense monomorphus infiltrate in dermis and positive immunostainings for CD3, CD99 and terminal deoxynucleotidyl transferase, thus indicating T‐LBL. Staging work‐up only revealed a mediastinal mass at diagnosis. After a 51‐month follow‐up and different treatment regimens, the patient remains alive although she has presented four relapses, all of them extramedullary.