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Histiocytoid Sweet syndrome harboring an isocitrate dehydrogenase 1 mutation: A case report and retrospective analysis of 29 cases of histiocytoid Sweet syndrome
Author(s) -
Libby Tiffany J.,
Fleming Kirsten,
Amin Bijal
Publication year - 2019
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13418
Subject(s) - isocitrate dehydrogenase , pathology , histiocyte , sweet syndrome , myelodysplastic syndromes , medicine , myeloid , leukemia , idh1 , myeloid leukemia , mutation , cancer research , biology , bone marrow , gene , genetics , enzyme , biochemistry
Histiocytoid Sweet syndrome (HSS) is a rare histopathologic variant of Sweet syndrome that demonstrates dermal and/or subcutaneous infiltrate with a prominent component of myeloid cells resembling histiocytes. It has been known to occur in association with hematologic neoplasms, including myelodysplastic syndrome (MDS) and acute myelogenous leukemia, but whether it confers an increased risk of such neoplasms is controversial. Here, we describe a case of a HSS that led to the diagnosis of MDS with an isocitrate dehydrogenase 1 (IDH‐1) mutation and a corresponding study looking for additional cases of IDH‐1 mutations in biopsies of histiocytoid and conventional Sweet syndrome.