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Pediatric CD8+/CD56+ mycosis fungoides with cytotoxic marker expression: A variant with indolent course
Author(s) -
Rovaris Marco,
Colato Chiara,
Girolomoni Giampiero
Publication year - 2018
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13317
Subject(s) - mycosis fungoides , medicine , asymptomatic , cd8 , dermatology , pathology , cytotoxic t cell , erythroderma , granzyme b , lymphoma , immunology , biology , immune system , biochemistry , in vitro
Mycosis fungoides is predominantly a disease of older patients, but occasionally occurs in children. We report a rare case of CD8+/CD56+ mycosis fungoides with cytotoxic marker (perforin, TIA‐1, and granzyme B) expression in a 10‐year‐old boy. Disease presented with three asymptomatic, slowly progressive erythematous and scaling plaques, surrounded by hypochromic alone in the left tight and lower trunk. UVB narrow band associated with topical corticosteroids resulted in complete remission in about 2 months, and no recurrence at 2‐year follow‐up. Three similar cases have been retrieved in children through PubMed search, showing similar clinical presentation with erythematous scaling lesions, good response to skin‐directed treatments and a favorable prognosis.