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Sarcomatoid pilomatrix carcinoma
Author(s) -
FernandezFlores Angel,
Cassarino David S.
Publication year - 2018
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13151
Subject(s) - pilomatricoma , pathology , cd34 , sarcomatoid carcinoma , cdx2 , medicine , mohs surgery , carcinoma , neoplasm , biology , stem cell , transcription factor , gene , biochemistry , genetics , homeobox
Pilomatrix (pilomatrical) carcinoma is a rare cutaneous adnexal tumor with matrical differentiation and recurrent and metastatic potential. Sarcomatoid pilomatrix carcinoma is a rare variant which shows a sarcomatoid component intermingling with the epithelial one. There are only 4 cases previously published. We present an additional case on the hand of a 78 year‐old man which appeared as a 6 mm hyperkeratotic, focally ulcerated plaque. A shave biopsy demonstrated a dermal infiltrative neoplasm, composed of markedly atypical‐appearing basaloid cells with focal necrotic/ghost cells, as well as an intimately associated population of atypical oval to spindle‐shaped cells. Both the epithelial and the sarcomatoid components expressed cytokeratins (CKs) AE1/AE3, CK 5/6 and CAM 5.2, as well as beta‐catenin and LEF‐1. The tumor failed to express CK7, CK20, S100, thyroid transcription factor 1 (TTF1), CDX2, prostate‐specific antigen (PSA) and CD34. The tumor was completely excised with Mohs surgery, and there has been no recurrence in the 8 months of follow‐up to date.

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