Premium
Indeterminate cell histiocytosis in a Chinese patient with progressive and extensive nodular lesions and mixed indeterminate cell and macrophage‐monocyte lineage
Author(s) -
Chen Qiping,
Lee Joyce S.S.,
Liang Michelle W.,
Chan Michelle M.F.,
Pujol Ramón M.,
Requena Luis,
Tan Suat Hoon
Publication year - 2018
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13132
Subject(s) - histiocyte , pathology , histiocytosis , langerin , cd68 , langerhans cell histiocytosis , giant cell , birbeck granules , medicine , langerhans cell , population , biopsy , s100 protein , immunohistochemistry , dendritic cell , antigen , immunology , disease , environmental health
Indeterminate cell histiocytosis (ICH) is an extremely rare cutaneous neoplastic disorder. It has the immunophenotypic features of both Langerhans and non‐Langerhans cell histiocytosis. We report here a case of a healthy young Chinese woman who presented with disfiguring, thick, infiltrated cutaneous nodules on the face, trunk and extremities which appeared progressively over a period of 4 years. No systemic involvement has been detected so far. Results of a skin biopsy showed diffuse dermal infiltration of histiocytoid cells with indented nuclei and positive staining for S100 and CD1a and negativity for CD207 (langerin). Admixed within were some CD68‐positive foamy histiocytes and multinucleated giant cells with focal expression of CD163. Although the clinical presentation is more typical of progressive nodular histiocytosis, the histology and immunoprofile is consistent with ICH. Our report adds to the limited case reports in the current literature of ICH in the Chinese population.