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Microcystic adnexal carcinoma with sebaceous differentiation: Three cases
Author(s) -
FernandezFlores Angel,
LlamasVelasco Mar,
Saus Carles,
Patel Anisha,
Rutten Arno
Publication year - 2018
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13109
Subject(s) - sebaceous carcinoma , apocrine , sebaceous gland , pathology , context (archaeology) , keratin , hair follicle , carcinoma , cellular differentiation , medicine , biology , paleontology , biochemistry , gene
Microcystic adnexal carcinoma (MAC) is a low‐grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous‐apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. In this context, sebaceous differentiation in MAC would support the first option. However, there are only 3 cases of MAC with sebaceous differentiation in the literature, and all of them were reported before adipophilin was available, which in the appropriate context (eg, testing clear cells for sebaceous vs eccrine differentiation) is very useful. In this study, we present 3 cases of MAC with focal sebaceous differentiation confirmed by immunoexpression of adipophilin in the sebaceous foci.