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Granular cell basal cell carcinoma: A case report
Author(s) -
Ma Xinyi,
Wang Guihua,
Kuwadekar Aditya,
Zhao Min,
Hu Weili,
Wu Yeqin,
Yi Zhongliang,
Xu Xianen,
Xu Li
Publication year - 2018
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13087
Subject(s) - pathology , cd68 , cytokeratin , eosinophilic , basal cell carcinoma , granular cell tumor , clone (java method) , basal (medicine) , mitotic index , immunohistochemistry , biology , basal cell , mitosis , anatomy , medicine , microbiology and biotechnology , dna , insulin , genetics , endocrinology
Granular cell basal cell carcinoma (BCC) is a rare histopathological variant of BCC. Our review of the literature revealed only 17 previously identified cases. We report the case of a 47‐year‐old man who presented with an ulceration on his right upper lip which was subsequently removed. Histopathologic examination revealed that the tumor was composed solely of granular cells with numerous cytoplasmic eosinophilic round inclusion bodies. Mitotic figures ranged from 8 to 15 per 10 high‐power fields, with a Ki‐67 proliferative index of ~5%. Immunohistochemically, the granular cells showed strong and diffuse positivity for Ber‐EP4, pan‐cytokeratin, AE1/AE3, CK5/6 and p63 and focal positivity for lysozyme, CD68 (clone KP1) and Bcl‐2.