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Nuclear and cytoplasmic features in the diagnosis of Clark's nevi
Author(s) -
Valdebran Manuel,
Bandino Justin,
Elbendary Amira,
Gad Abdallah,
Arudra Krishna C.,
de Feraudy Sébastien,
Elston Dirk M.
Publication year - 2018
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13085
Subject(s) - pathology , medicine , dermatology , nevus , melanoma , cancer research
Background Interpretation of Clark's nevi has generated debate over the years; although criteria have been proposed for grading morphological features of melanocytes, there is still confusion and variability in the assessment of these lesions. Methods This is a retrospective observational study conducted on 100 Clark's nevi and 84 melanomas. A single expert dermatopathologist evaluated all blinded and randomized photomicrographs of both the Clark's nevi and melanomas for the presence of 14 cytologic features. Subsequently, a multivariate model was used to obtain sensitivity and specificity. Results Clark's nevi showed a significantly higher frequency of absent‐or‐inconspicuous nucleoli over melanoma, whereas mitotic figures, pleomorphism, notching, multiple nucleoli, peppered moth nuclear pattern, flattened adjacent nuclei, prominent nucleoli and vesicular nucleus with rounded nucleoli were found significantly higher in frequency in melanomas. Conclusion Our data suggest that nuclear alterations are of value in the differentiation of atypical nevi from melanoma.