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Immunohistochemical markers informing the diagnosis of sebaceous carcinoma and its distinction from its mimics: Adipophilin and factor XIIIa to the rescue?
Author(s) -
Tetzlaff Michael T.
Publication year - 2018
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13073
Subject(s) - sebaceous carcinoma , immunohistochemistry , pathology , basal cell carcinoma , basal cell , carcinoma , medicine , factor xiiia , concomitant
Sebaceous carcinoma typically presents a diagnostic challenge because it mimics other more common, locally invasive carcinomas, including squamous cell carcinoma and basal cell carcinoma—particularly when one of these tumors exhibits concomitant clear‐cell changes. Immunohistochemical studies offering high sensitivity and specificity are critical for accurate diagnosis.