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Leiomyosarcoma of the great saphenous vein ( vena saphena magna ) with granular cell change: Report of a superficial neoplasm
Author(s) -
Macarenco Ricardo S.,
Filippi Renee Z.,
D’Almeida Costa Felipe,
JesusGarcia Reynaldo
Publication year - 2018
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13062
Subject(s) - medicine , great saphenous vein , leiomyosarcoma , vein , biopsy , radiology , surgery , pathology
The great saphenous vein (GSV) corresponds to the main superficial large‐caliber vessel affected by leiomyosarcoma (LMS). Given its superficial location and because signs of vascular origin may not be clinically apparent, LMS of the GSV may be misinterpreted clinically as superficial nonvascular soft tissue mass. Herein, we report a case on the distal portion of the right GSV of a 57‐year‐old man. The histopathological recognition of a large‐caliber vein‐associated LMS (with granular cell change) in an incisional biopsy specimen was crucial to guide radiological evaluation and confirmation of a superficial vascular LMS before surgical treatment. Recognizing this entity in small biopsies is important as its surgical treatment and prognosis differ substantially from nonvascular superficial (ie, subcutaneous and dermal) LMSs. In addition, because vascular LMSs can involve long vessel segments, underestimation of extent of disease is a risk. To the best of our knowledge, granular cell change has not been documented in LMS of the GSV.