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An interesting case of pyoderma gangrenosum with immature hystiocytoid neutrophils
Author(s) -
Besner Morin Catherine,
Côté Benoit,
Belisle Annie
Publication year - 2018
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13053
Subject(s) - pyoderma gangrenosum , sweet syndrome , pathology , histopathology , medicine , leukemia cutis , cutis , hematopathology , neutrophilic dermatosis , pyoderma , stain , dermatology , bone marrow , staining , biology , cytogenetics , disease , biochemistry , chromosome , gene
We present a unique case of a 36‐year‐old male who developed more than 20 pyoderma gangrenosum (PG) ulcers showing on histopathology a dense inflammatory infiltrate composed of histiocytoid mononuclear immature cells with a strong positivity for myeloperoxidase and Leder stain, suggesting a myeloid lineage in the absence of a concomitant myeloproliferative disorder. Histiocytoid Sweet syndrome (SS) is now recognized as a histological subtype of SS. Although PG and SS belong to the spectrum of neutrophilic diseases, to the best of our knowledge, this is the first case of a “Histiocytoid pyoderma gangrenosum” encompassing immature granulocytes in the absence of leukemia cutis.