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Congenital neurocristic cutaneous hamartoma with poliosis: A case report
Author(s) -
Wilson Lauren M.,
Beasley Knox J.,
Sorrells Timothy C.,
Johnson Viviana V.
Publication year - 2017
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.13027
Subject(s) - pathology , medicine , hamartoma , dermis , neural crest , dermatology , scalp , stain , anatomy , staining , biology , embryo , microbiology and biotechnology
Neurocristic cutaneous hamartomas ( NCH ) are rare, pigmented skin lesions derived from the abnormal migration of neural crest cells. We report the case of a 57‐year‐old female with a congenital localized area of poliosis and underlying pigmented patch on her scalp. Analysis of 2 punch biopsies yielded features consistent with NCH . Histopathology revealed schwannian‐differentiated spindle cells and melanocytic components in the dermis. The spindle cells stained positively for S‐100 and the stroma showed a prominent CD34 staining. The melanocytes were positive for melanoma triple stain ( HMB ‐45, Melan A, Tyrosinase) and S‐100. As the presentation of NCH and focal poliosis has yet to be described, we will present a literature review of NCH and discuss common features and associations of poliosis.