Congenital neurocristic cutaneous hamartoma with poliosis: A case report

Neurocristic cutaneous hamartomas ( NCH ) are rare, pigmented skin lesions derived from the abnormal migration of neural crest cells. We report the case of a 57‐year‐old female with a congenital localized area of poliosis and underlying pigmented patch on her scalp. Analysis of 2 punch biopsies yielded features consistent with NCH . Histopathology revealed schwannian‐differentiated spindle cells and melanocytic components in the dermis. The spindle cells stained positively for S‐100 and the stroma showed a prominent CD34 staining. The melanocytes were positive for melanoma triple stain ( HMB ‐45, Melan A, Tyrosinase) and S‐100. As the presentation of NCH and focal poliosis has yet to be described, we will present a literature review of NCH and discuss common features and associations of poliosis.