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Hereditary progressive mucinous histiocytosis: 3 different phenotypes in 3 family members
Author(s) -
Requena Celia,
Requena Luis,
Traves Victor,
Sanmartín Onofre
Publication year - 2017
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12970
Subject(s) - histiocyte , pathology , medicine , histiocytosis , daughter , disease , phenotype , langerhans cell histiocytosis , dermatology , clinical phenotype , biology , genetics , evolutionary biology , gene
We describe 3 cases of multiple histiocytic cutaneous tumors that began in childhood and affected 3 members from 2 generations of the same family: a mother, a daughter and a nephew. The lesions were mostly skin‐colored papules distributed symmetrically on the dorsum of the forearms and hands and on the face and thighs. There were no signs of spontaneous regression. The clinical and histopathological features were consistent with a diagnosis of hereditary progressive mucinous histiocytosis ( HPMH ), but phenotypic expression varied somewhat between the 3 patients. HPMH has only been described in 8 families to date, and just one of the reports included 3 well‐documented cases. Our cases confirm that HPMH can affect males and expands the clinical spectrum of skin lesions in this disease.