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Disseminated CD8 ‐positive, CD30 ‐positive cutaneous lymphoproliferative eruption with overlapping features of mycosis fungoides and primary cutaneous anaplastic large cell lymphoma following remote solitary lesional presentation
Author(s) -
Davick Jonathan J.,
Mutgi Krishna A. J.,
Wanat Karolyn A.,
Link Brian K.,
Liu Vincent
Publication year - 2017
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12961
Subject(s) - lymphomatoid papulosis , mycosis fungoides , cd30 , medicine , anaplastic large cell lymphoma , cutaneous lymphoma , pathology , lymphoma , lymphoproliferative disorders , cd8 , large cell lymphoma , large cell , dermatology , immunology , antigen , cancer , adenocarcinoma
CD8 ‐positive, CD30 ‐positive cutaneous lymphoproliferative disorders constitute a rare subset of T‐cell lymphoproliferative conditions, including variants of primary cutaneous anaplastic large cell lymphoma (ALCL), mycosis fungoides, lymphomatoid papulosis type D, cutaneous gamma‐delta T‐cell lymphoma and cutaneous peripheral T‐cell lymphoma. These entities share overlapping clinical, histopathologic and immunophenotypic features, presenting both a clinical and pathological diagnostic challenge. Presented here is a 73‐year‐old man with a disseminated, indolent CD30 +, CD8 + cutaneous lymphoproliferative disorder with overlapping clinical and histopathological features of both mycosis fungoides and primary cutaneous ALCL, as well as features of lymphomatoid papulosis. To our knowledge, this is the first case of a generalized CD8 +, CD30 + eruption with features of both mycosis fungoides and primary cutaneous ALCL arising following an episode of solitary primary cutaneous CD8 ‐positive ALCL.