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MYD88 L265P mutation in cutaneous involvement by Waldenström macroglobulinemia
Author(s) -
AlegríaLanda Victoria,
PrietoTorres Lucía,
Santonja Carlos,
Córdoba Raul,
Manso Rebeca,
Requena Luis,
RodríguezPinilla Socorro M.
Publication year - 2017
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12944
Subject(s) - waldenstrom macroglobulinemia , pathology , medicine , infiltration (hvac) , biopsy , lymphoplasmacytic lymphoma , macroglobulinemia , bone marrow , lesion , lymphoma , immunology , multiple myeloma , physics , thermodynamics
Cutaneous manifestations of Waldenström macroglobulinemia (WM) may occur because of several mechanisms, the least common being direct skin infiltration by neoplastic cells. We report a case of patient that after 4‐year history of indolent WM developed skin infiltration by lymphoplasmacytoid cells in the form of a small, mildly indurated plaque on the anterior chest. MYD88 L265P mutation was detected both in the previous bone marrow biopsy and in the cutaneous lesion. We review the impact of this new genetic tool in the diagnosis and treatment of lymphoplasmacytic proliferations.